Spatial Multi-omics Imaging
Deep Learning for Image Segmentation
Deep Learning for Image Super-Resolution
Super-Resolution Fluorescence Microscopy
BACKGROUND INFORMATION
Karl Zhanghao is an Associate Professor and Ph.D. advisor at the Eastern Institute of Technology, Ningbo. He received his Bachelor's degree in Microelectronics from Peking University in 2012 and his Ph.D. in Biomedical Engineering from Peking University and the Georgia Institute of Technology in 2017. He has previously served as Boya Postdoc at Peking University, Research Assistant Professor at the Southern University of Science and Technology, and as a Senior Engineer at BGI Life Sciences Research Institute. His research focuses on digital cell imaging, aiming to construct cellular maps of the brain or pathological tissues through technology breakthroughs in high-throughput, high-content, high/super-resolution imaging and deep learning image processing, as well as the industrial automation of existing multi-omics detection technologies. In recent years, he has published 12 papers as first author or corresponding author in journals or conferences such as Nat Comm (x2), Light Sci Appl (x2), Appl Phys Lett, Optics Lett, etc. He has led 5 research projects including national-level funds and has been awarded the Overseas High-level Talent by the Shenzhen Municipal Government, the Croucher Foundation Travel Scholarship by the University of Hong Kong, and the Peking University Boya Postdoctoral Fellowship, among other honors.
RESEARCH FIELD
Spatial Multi-omics Imaging
Deep Learning for Image Segmentation
Deep Learning for Image Super-Resolution
Super-Resolution Fluorescence Microscopy
EDUCATIONAL BACKGROUND
2012.09 - 2017.07：PhD.（majoring in biomedical engineering），Peking University，department of biomedical engineering
2013.01 - 2017.08：PhD.（majoring in biomedical engineering），Georgia Institute of Technology / Emory University，department of biomedical engineering
2007.09 - 2012.07：Bachelor（majoring in microelectronics），Peking University，Yuanpei college
WORK EXPERIENCE
2022.07-2024.04: BGI Research Shenzhen，senior engineer
2019.09-2022.07: Southern University of Science and Technology, research assistant professor
2017.06 - 2019.09：Peking University，Boya postdoctoral fellow
AWARDS AND HONORS
2020.01：Shenzhen Overseas High-Caliber Personnel
2019.08：the Croucher Foundation travel grant
2017.07：Boya Postdoctoral Fellowship
GENERAL INFORMATION
More than 26 SCI papers
WORKS INFORMATION AND CITATION DATA
Google Scholar：
https://scholar.google.com/citations?user=ZG7NqrwAAAAJ
Web of Knowledge：
https://www.webofscience.com/wos/author/record/1805882
ResearchGate:
https://www.researchgate.net/profile/Karl-Zhanghao
REPRESENTATIVE WORKS (* refers to the corresponding author)
1. G. Wen#, H.J. Li#, H.J. Wang, Q. Ke, J.Q. Wang, X. Zhu, Y. Chen, D.Y. Jin, S.C. Chen, K. Zhanghao*. Pyramidal lens enables mesoscale structured illumination by surpassing the spatial bandwidth limit of spatial light modulators. Optica 12, 1180-1191 (2025)
2. K. Zhanghao#, M.Q. Li#*, X.Y. Chen, W.H. Liu, T.L. Li, Y.M. Wang, F. Su, Z.H. Wu, C.Y. Shan, J.M. Wu, Y. Zhang, J.Y. Fu, P. Xi*, D.Y. Jin*. Fast segmentation and multiplexing imaging of organelles in live cells. Nat Commun 16, 2769 (2025).
3. F. Zhou, Y.H. Liu, Z. Chen, K. Zhanghao*, D.Y. Jin*. Fourier Channel Attention Powered Lightweight Network for Image Segmentation. IEEE Journal of Translational Engineering in Health and Medicine, 11:252-260(2023)
4. L. Qiao#, H.J. Li#, S.Y. Zhong#, X.Z. Xu, F. Su, P. Xi, D.Y. Jin*, K. Zhanghao*. Laterally swept light-sheet microscopy enhanced by pixel reassignment for photon-efficient volumetric imaging. Advanced Photonics Nexus 2, (2022).
5. M.L. Guan#, M.Y. Wang#, K Zhanghao#, X. Zhang, M.Q. Li, W.H. Liu, J. Niu, X.S. Yang, L. Chen, Z.L. Jing, M.Q. Zhang, D.Y. Jin, P. Xi, J.T. Gao†. Polarization Modulation with Optical Lock-in Detection Reveals Universal Fluorescence Anisotropy of Subcellular Structures in Live Cells. Light: Science & Applications 2022, 11(1).
6. H.J. Li, Z.H. Wu, Z.C. Yang, K. Zhanghao*, P. Xi, D.Y. Jin. Axially Overlapped Multi-Focus Light Sheet with Enlarged Field of View. Applied Physics Letters, 118, 223701 (2021).
7. K. Zhanghao#, *, W.H. Liu#, M.Q. Li#, Z.H. Wu, X.S. Wang, X.Y. Chen, C.Y. Shan, H.Q. Wang, X.W. Chen, Q.H. Dai, D.Y. Jin*, P. Xi*. High-dimensional Super-Resolution Imaging Reveals Heterogeneity and Dynamics of Subcellular Lipid Membranes. Nature Communications, 11, 5890 (2020)
8. M.Q. Li#, Y.N. Li#, W.H. Liu, A. Lai, S. Jiang, D.Y. Jin, H.P. Yang, S. Wang, K. Zhanghao*, P. Xi.*. Structured Illumination Microscopy using Digital Micro-mirror Device and Coherent Light Source. Applied Physics Letters 116, 233702 (2020).
9. K. Zhanghao#, *, X. Chen#, W. Liu, M.Q. Li, Y.Q. Liu, Y.M. Wang, S. Luo, X. Wang, C.Y. Shan, H. Xie, J.T. Gao, X.W. Chen, D.Y. Jin, X.D. Li, Y. Zhang, Q. Dai*, P. Xi*. Super-resolution Imaging of Fluorescent Dipoles via polarized structured illumination microscopy. Nature Communications 10, 4694 (2019).
10. K. Zhanghao#, L. Chen#, X.S. Yang, M.Y. Wang, Z.L. Jing, H.B. Han, M. Q. Zhang, D.Y. Jin*, J.T. Gao*, P. Xi*. Super-resolution Dipole Orientation Mapping via Polarization Demodulation, Light: Science & Applications, 2016, 5(10).
